ATF4

ATF4
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1CI6
Identifiants
Aliases	ATF4
IDs externes	OMIM: 604064 MGI: 88096 HomoloGene: 1266 GeneCards: ATF4
Position du gène (Homme) Chr. Chromosome 22 humain Locus 22q13.1 Début 39,519,695 bp Fin 39,522,683 bp
Position du gène (Souris) Chr. Chromosome 15 (souris) Locus 15 E1|15 37.85 cM Début 80,139,385 bp Fin 80,141,742 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans artère poplitée body of stomach subcutaneous adipose tissue fundus artère coronaire droite body of pancreas artère coronaire gauche prostate aorte ascendante muqueuse gastrique Fortement exprimé dans articulation talo-crurale calvaria glande lacrymale muscle plantaire Muscle temporal îlot de Langerhans muscle triceps brachial parotide muscle long extenseur des orteils superior surface of tongue Plus de données d'expression de référence BioGPS n/a
Gene Ontology Fonction moléculaire liaison ADN sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding protein C-terminus binding liaison protéique leucine zipper domain binding protein heterodimerization activity protein kinase binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Composant cellulaire cytoplasme ATF1-ATF4 transcription factor complex ATF4-CREB1 transcription factor complex transcription regulator complex dendrite membrane noyau Lewy body core nuclear periphery membrane membrane plasmique nucléoplasme Centre organisateur des microtubules neuron projection cytosquelette CHOP-ATF4 complex centrosome complexe macromoléculaire RNA polymerase II transcription regulator complex Processus biologique gamma-aminobutyric acid signaling pathway néoglucogenèse regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of transcription by RNA polymerase II negative regulation of oxidative stress-induced neuron death cellular response to amino acid starvation mRNA transcription by RNA polymerase II circadian regulation of gene expression response to endoplasmic reticulum stress PERK-mediated unfolded protein response response to manganese-induced endoplasmic reticulum stress régulation positive de la transcription dépendante de l'ADN positive regulation of neuron apoptotic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of gene expression positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress rythme circadien negative regulation of potassium ion transport positive regulation of transcription by RNA polymerase II positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance cellular response to glucose starvation negative regulation of translational initiation in response to stress processus rythmique cellular response to UV positive regulation of transcription from RNA polymerase II promoter in response to stress cellular amino acid metabolic process transcription by RNA polymerase II transcription, DNA-templated positive regulation of apoptotic process positive regulation of vascular endothelial growth factor production positive regulation of transcription by RNA polymerase I cellular response to dopamine réponse à une substance toxique différenciation d'un neurone cellular response to oxygen-glucose deprivation positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular calcium ion homeostasis positive regulation of biomineral tissue development negative regulation of cold-induced thermogenesis positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of sodium-dependent phosphate transport Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 468 11911 Ensembl ENSG00000128272 ENSMUSG00000042406 UniProt P18848 Q06507 RefSeq (mRNA) NM_182810 NM_001675 NM_001287180 NM_009716 RefSeq (protéine) NP_001666 NP_877962 NP_001274109 NP_033846 Localisation (UCSC) Chr 22: 39.52 – 39.52 Mb Chr 15: 80.14 – 80.14 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

L'ATF4 (pour « Activating transcription factor 4 ») est un facteur de transcription de la famille des ATF dont le gène est ATF4 situé sur le chromosome 22 humain.

Rôles

L'ATF4 intervient pour la transcription de plusieurs gènes jouant sur le métabolisme cellulaire. Son activité favorise la prolifération tumorale ainsi que la résistance aux traitements anticancéreux comme pour le cisplatine.

Il intervient également dans l'embryogenèse.

Au cours d'un stress, en particulier de nature hypoxique, son activité est fortement diminuée.