Apoliprotéine C-I

APOC1
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1ALE, 1ALF, 1IOJ, 1OPP
Identifiants
Aliases	APOC1
IDs externes	OMIM: 107710 MGI: 88053 HomoloGene: 136749 GeneCards: APOC1
Position du gène (Homme)
Chr.	Chromosome 19 humain
Fin	44,919,349 bp
Position du gène (Souris)
Chr.	Chromosome 7 (souris)
Fin	19,426,585 bp
Expression génétique
	Fortement exprimé dans
	right lobe of liver; ; noyau accumbens; ; putamen; ; noyau caudé; ; poumon droit; ; rate; ; substantia nigra; ; hypothalamus; ; ganglion lymphatique; ; upper lobe of left lung;
	Fortement exprimé dans
	left lobe of liver; ; vésicule biliaire; ; lèvre; ; tissu adipeux brun; ; Vésicule vitelline; ; œsophage; ; blastocyste; ; subcutaneous adipose tissue; ; tissu adipeux blanc; ; skin of back;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding; phosphatidylcholine-sterol O-acyltransferase activator activity;
Composant cellulaire	Chylomicron; very-low-density lipoprotein particle; réticulum endoplasmique; high-density lipoprotein particle; région extracellulaire;
Processus biologique	lipid transport; chylomicron remnant clearance; negative regulation of fatty acid biosynthetic process; processus métabolique lipidique; positive regulation of cholesterol esterification; phospholipid efflux; cholesterol metabolic process; negative regulation of phosphatidylcholine catabolic process; plasma lipoprotein particle remodeling; negative regulation of very-low-density lipoprotein particle clearance; regulation of cholesterol transport; negative regulation of receptor-mediated endocytosis; high-density lipoprotein particle remodeling; cholesterol efflux; negative regulation of cholesterol transport; negative regulation of lipoprotein lipase activity; very-low-density lipoprotein particle assembly; negative regulation of lipid catabolic process; triglyceride metabolic process; negative regulation of lipid metabolic process; positive regulation of catalytic activity; very-low-density lipoprotein particle clearance; lipoprotein metabolic process;
	Sources:Amigo / QuickGO
Orthologues
	341
	11812
	ENSG00000130208
	ENSMUSG00000040564
	P02654
	P34928
	NM_001645; NM_001321065; NM_001321066; NM_001379687
	NM_001110009; NM_007469
	NP_001307994; NP_001307995; NP_001636; NP_001366616
	NP_001103479; NP_031495
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

L'apolipoprotéine C-I est l'une des quatre apolipoprotéine C. Son gène est APOC1 situé sur le chromosome 19 humain.

Rôle[modifier | modifier le code]

Il inhibe la capture hépatique des VLDL^[5], augmentant le taux sanguin de ce dernier.

En médecine[modifier | modifier le code]

Son taux est corrélé avec celui des triglycérides sanguins et la présence d'un athérome carotidien^[6].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000130208 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000040564 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Jong MC, Dahlmans VE, van Gorp PJ et al. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway, J Clin Invest, 1996;98:2259–2267
↑ Hansen JB, Fernández JA, Notø AT, Dequchi H, Björkegren J, Mathiesen EB, The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis, J Lipids, 2011;2011:271062

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000130208 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000040564 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Jong_1996-5] Jong MC, Dahlmans VE, van Gorp PJ et al. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway, J Clin Invest, 1996;98:2259–2267

[Hansen_2011-6] Hansen JB, Fernández JA, Notø AT, Dequchi H, Björkegren J, Mathiesen EB, The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis, J Lipids, 2011;2011:271062

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